From the Horse's Mouth

"We are going to be doing 'Scream 4.' Hopefully Wes Craven is going to direct."

Those were the recent words of David Arquette, who confirmed his (and his wife's) involvement in the revival of the Scream franchise, which will include three new sequels that will serve as an all new trilogy.

At this point, no plot details have been revealed and there's still no sign that Neve Campbell may return.

I don't think she will, which means this still has flop written all over it.